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Sathees C Raghavan
Assistant Professor
Department of Biochemistry
Indian Institute of Science
Bangalore 560 012
Tel: +91 80 2293 2674 (work)
+91 80 2360 5941 (home)
+91 99860 27444 (mobile)
Fax: +91 80 2360 0814
email : sathees@biochem.iisc.ernet.in, sathees.raghavan@gmail.com
http://biochem.iisc.ernet.in/sathees.htm

Areas of Research Interests
    Cancer Genetics and Cancer Therapeutics
    V(D)J recombination
DNA double-strand break repair Stem cell biology

Educational qualifications
  1982-1985 High School (SSLC) First Class, 83 % Biology, Chemistry, Physics, Mathematics, English, Hindi, Malayalam Board of Public Exams, Kerala, India
  1985-1987 Pre degree First Class, 66 % Chemistry, Physics, Biology, English, Hindi Calicut University, Kerala, India
  1987-1990 B.Sc. Zoology First Class, 88 % Zoology, Chemistry, Botany, English, Hindi Calicut University, Kerala, India
  1990-1992 M.Sc Zoology First Class, 78 % Zoology, Entomology Biochemistry, Mol. BiologyBiophysics, Ecology Calicut University, Kerala, India
  1993-1999 Ph.D. in Zoology Molecular Biology, Biochemistry, Cell Biology Banaras Hindu University,Varanasi, UP, India
1999-2006 Postdoctoral Research Cancer biolog y, MolecularBiolog y, Biochemistry, Structural Biology Norris Cancer Ctr, University of Southern California, Los Angeles, CA, USA
2006 April- todate Assistant Professor Cancer Genetics, Molecular Biology, DNA Repair and Recombination Department of Biochemistry, Indian Institute of Science, Bangalore, 560 012 INDIA

Title of Ph.D. Thesis
Characterization of DNA Double-Strand BreakRepair in Mouse Testicular Cell-Free Extracts

Scholarship/Fellowship
 UniversityMerit Scholarship, B.Sc.(1987-1990)
 University Merit Scholarship, M.Sc. (19901992)
 UGC Junior Research Fellowship, India (1993-1995)
 UGC Senior Research Fellowship, India (1995-1998)
 Post Doctoral Fellowship of NIH, USA (1999-2006)

Merits
 III Rank in B.Sc. Zoology
 IV Rank in M.Sc. Zoology
 GATE-1992 (Graduate Aptitude Test inEngineering)

Current Research Topics

  • Chromosomal translocation in cancer: Mechanisms and development of cancer
  • Cancer therapeutics: Designing drugs, functional and structural characterization and its roles in regression of cancers, both in vivo and in vitro
  • RAG c le avag e me cha ni sm s at recombination signal sequences and non-B DNA structures
  • Non homologous DNA end-joining
  • Stem cell biology

Experiences
  • Worked in the field of DNA double- strand break repair of mammalian testicular cells for 6years at Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University,Varanasi, India (1993-1999). (Title of Ph.D. thesis: Characterization of DNA double-strandbreak repair in mouse testicular cell-free extracts; Name of Supervisor: Prof. MercyJ.Raman, Ph.D) 6 years and 6 months post doctoral research experience at Department ofPathology, Norris Cancer Ctr, Rm 5428, University of Southern California, Keck School of Medicine, 1441 Eastlake Ave, MC9176, Los Angeles, CA, 90033, USA, in the field of cancer biology related to lymphoid chromosomal translocations (19992006. (Name of Postdoctoral Mentor : Prof. Michael R Lieber M.D., Ph.D).
  • Experience in planning and meticulous execution of experiments and data analysis (1994-2007).
  • Participated and presented scientific work in national and international symposia (see alsounder professional recognition section).
  • Participated in a workshop on " Dosimetry Techniquesin Radiobiology" organized by Association of medical physicists ofIndia at BARC, Mumbai, 1993.
  • Worked as demonstrator in the national Training course on "Molecular and Chromosomal techniques in Clinical and Human Genetics", 1999.
  • Worked as a resource person in during UGC sponsored refresher course in Biotechnology and Bioinformatics for university and college teachers at University of Calicut, Calicut, India., 2006
  • Selection Committee Member for admissions of 6th batch students (2006) in Institute of Bioinformatics and Applied Biotechnology (IBAB), Bangalore, India.
  • Experience in various computerprogrammes, such as Microsoft Word, Excel, PowerPoint, ImageQuant, Adobe Photoshop, Canvas, Origin, EndNote, DNAstrider, DNAstar etc.
  • Working as Assistant Professor in the Department of Biochemistry, Indian Institute of Science, Bangalore, since April 19, 2006.
  • Experience in reviewing scientific articles for various journals, since 2000.

Research publications
Has totally 19 National & International publications to his credit.

His Topic at Bio Rujivith
Chromosomal Translocation in Cancer

a chromosome translocation is a chromosome abnormality caused byrearrangement of parts between nonhomologous chromosomes. It is detected on cytogenetics or a karyotype of affected cells. There are two main types, reciprocal (also known as non- Robertsonian) and Robertsonian. Also, translocations can be balanced (in an even exchange of material with no genetic information extra or missing, and ideally full functionality) or unbalanced (where the exchange of chromosome material is unequalresulting in extra or missing genes

 Chromosomal translocations bring two previously unlinked segments of the genome together, which in some cases can result in disease by inducinginappropriate expression of a protein or synthesis of a new fusion protein. This phenomenon is particularly important when the break point of the translocation affects an oncogene and results in cancer. In fact, the study oftranslocations in neoplastic cells provided some of the best earlyevidence in support of a genetic basis for cancer